Why the study?
Does ATL-146e reduce stress-induced gastric lesions in rats?
Population
Rats subjected to water-immersion stress
Comparison
Pretreatment with a single intraperitoneal… vs Control rats
Design
Preclinical
Authors
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ATL-146e attenuates stress-induced gastric lesions in rats; hypothesis-generating for A2A agonism in human gastroprotection.
Does ATL-146e reduce stress-induced gastric lesions in rats?
The adenosine A2A receptor agonist ATL-146e significantly reduces stress-induced gastric inflammation and mucosal damage in a rat model.
Odashima et al. (2005) studied this question.
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