What question did this study set out to answer?

The research aims to explore how tumor necrosis factor (TNF) interacts with bacterial products to cause severe adverse effects in mice.

January 1, 1988Proceedings of the National Academy of SciencesOpen Access

Synergy between tumor necrosis factor and bacterial products causes hemorrhagic necrosis and lethal shock in normal mice.

View Full Paper

Ask AI

Bookmark

Authors

JRJay L. RothsteinKubota (Japan)HSHans SchreiberUniversity of Chicago

Discussion

Member takes

Implication

Randomized trial demonstrates lethal shock in normal mice due to synergy between TNF and bacterial products, implying significant implications for infection response.

Key Points

The research aims to explore how tumor necrosis factor (TNF) interacts with bacterial products to cause severe adverse effects in mice.
Normal mice received TNF or bacterial products like lipopolysaccharide through various routes.
Combined doses of TNF and endotoxin were assessed for their effects on mouse skin and overall toxicity.
Lymphotoxin and other cytokines were tested for their ability to induce similar effects in conjunction with TNF.
High doses of TNF alone did not cause hemorrhagic necrosis; however, TNF with lipopolysaccharide led to lethal shock.
Subcutaneous lipopolysaccharide made skin more susceptible to hemorrhagic necrosis induced by TNF.
Lymphotoxin also caused hemorrhagic necrosis when combined with bacteria, unlike interleukin 1 alpha or interferon gamma.

Cite This Study

Rothstein et al. (1988) studied this question.

synapsesocial.com/papers/6a6f3bcb2163a0a01bc38fb5 https://doi.org/10.1073/pnas.85.2.607

View Full Paper

Ask AI

Bookmark

Implication

Randomized trial demonstrates lethal shock in normal mice due to synergy between TNF and bacterial products, implying significant implications for infection response.

Synergy between tumor necrosis factor and bacterial products causes hemorrhagic necrosis and lethal shock in normal mice.

Discussion

Member takes

Implication

Key Points

Cite This Study

Synergy between tumor necrosis factor and bacterial products causes hemorrhagic necrosis and lethal shock in normal mice.

Discussion

Member takes

Implication

Key Points

Cite This Study

Also Consider

Also Consider