What question did this study set out to answer?

Establish reference intervals for plasma malondialdehyde (P-MDA) and determine how age, sex, and lifestyle habits influence its concentration.

July 1, 1997Clinical ChemistryOpen Access

Plasma malondialdehyde as biomarker for oxidative stress: reference interval and effects of life-style factors

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Authors

FNFlemming NielsenUniversity of Southern Denmark BMBo Borg MikkelsenOdense Municipality JNJesper Bo NielsenRoskilde University

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Implication

Observational study reveals reference intervals and lifestyle influences on plasma malondialdehyde in healthy adults, suggesting group-level utility for oxidative stress tracking.

Key Points

Establish reference intervals for plasma malondialdehyde (P-MDA) and determine how age, sex, and lifestyle habits influence its concentration.
Evaluated 213 healthy adults (107 men, 106 women; ages 20–79 years) from Funen, Denmark.
Quantified P-MDA in EDTA plasma via thiobarbituric acid derivatization and HPLC with ultraviolet detection at 532 nm.
Calculated reference intervals using IFCC-recommended REFVAL 3.42 software and evaluated associations with age, sex, smoking, and alcohol use.
The reference interval (2.5th to 97.5th percentiles) for P-MDA was established at 0.36 to 1.24 µmol/L.
Concentrations were significantly affected by sex (P = 0.03) but not age (P = 0.11), with higher levels observed in daily smokers versus nonsmokers (P = 0.05).
P-MDA correlated positively with daily cigarette exposure (r = 0.162; P = 0.03) and weekly alcohol intake (r = 0.153; P = 0.03), though high within-subject day-to-day variation limits its diagnostic value for individuals.

Cite This Study

Nielsen et al. (1997) studied this question.

synapsesocial.com/papers/6a6f3c03f44fa9f079dca5d5 https://doi.org/10.1093/clinchem/43.7.1209

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Implication

Observational study reveals reference intervals and lifestyle influences on plasma malondialdehyde in healthy adults, suggesting group-level utility for oxidative stress tracking.

Plasma malondialdehyde as biomarker for oxidative stress: reference interval and effects of life-style factors

Discussion

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Implication

Key Points

Cite This Study

Plasma malondialdehyde as biomarker for oxidative stress: reference interval and effects of life-style factors

Discussion

Member takes

Implication

Key Points

Cite This Study

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