August 1, 1998EndocrinologyOpen Access

Overexpression of an Inhibitory Insulin-Like Growth Factor Binding Protein (IGFBP), IGFBP-4, Delays Onset of Prostate Tumor Formation1

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Why the study?

Does overexpression of IGFBP-4 delay tumor formation and enhance apoptosis in malignant prostate epithelial cells?

Population

Malignant M12 prostate epithelial cell line and male athymic/nude mice

Comparison

Overexpression of the IGF-inhibitory IGFBP-4 vs Control cells (M12 controls)

Design

Preclinical

Authors

SDSusan E. DamonUniversity of Puget Sound LMLisette A. MaddisonVanderbilt University JWJoy L. WareDuke University

Discussion

Member takes

Implication

Does not alter prostate cancer management; leaves open IGFBP-4 as a target for further preclinical validation.

Structured PICO

Does overexpression of IGFBP-4 delay tumor formation and enhance apoptosis in malignant prostate epithelial cells?

Population

Malignant M12 prostate epithelial cell line and male athymic/nude mice

Intervention

Overexpression of the IGF-inhibitory IGFBP-4

Comparator

Control cells (M12 controls)

Outcome

Tumor formation and apoptosissurrogate

Overexpression of the inhibitory IGFBP-4 delays the growth of malignant prostate epithelial cells and enhances their sensitivity to apoptosis in preclinical models.

Cite This Study

Damon et al. (1998) studied this question.

synapsesocial.com/papers/6a6f3ca9e5469ee92be042c5 https://doi.org/10.1210/endo.139.8.6150

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Overexpression of an Inhibitory Insulin-Like Growth Factor Binding Protein (IGFBP), IGFBP-4, Delays Onset of Prostate Tumor Formation1

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Overexpression of an Inhibitory Insulin-Like Growth Factor Binding Protein (IGFBP), IGFBP-4, Delays Onset of Prostate Tumor Formation1

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider