Condensation Nucleation Light Scattering Detection (Cnlsd) for Ion Chromatography

Ion chromatography (IC) combined with condensation nucleation light scattering detection (CNLSD) is shown here to be a highly sensitive method for cationic species determination, with limits-of-detection (LODs) at ng/mL levels. Furthermore, unlike the common conductivity detection method, higher than normally used acid concentration eluents can be used, resulting in faster elution of the analytes. The use of a suppressor is also eliminated since CNLSD is mainly dependent on the involatility of the analyte relative to the mobile phase, making the detection method universal for most cationic species. Investigative studies were also done on anion separations. In this case, a suppressor was required to improve the background level. Although detection limits for anionic species were not as low as for the cationic species, the results showed CNLSD to be a viable detector for anions, as well.