Key result
Specific concerns about antidepressant side effects strongly predicted antidepressant nonuse over 6 months (OR 3.30; 95% CI 2.20-4.97).
Population
178 patients aged 18 to 74 years, newly issued with a prescription for antidepressants to treat any…
Design
Cohort
Follow-up
6 months
Authors
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Side-effect concerns may hinder antidepressant adherence in primary care; leaves open whether addressing them improves persistence in trials.
Cohort (n=178)
Yes
Odds Ratio: 3.3 (95% CI 2.2–4.97)
Patient concerns about side effects and a mismatch between preferred and prescribed treatments are significant barriers to sustained antidepressant adherence in primary care.
Hunot et al. (2007) conducted a cohort in Any condition requiring antidepressants (n=178). Specific concern about antidepressant side effects was evaluated on Antidepressant nonuse (OR 3.30, 95% CI 2.20-4.97). Specific concerns about antidepressant side effects strongly predicted antidepressant nonuse over 6 months (OR 3.30; 95% CI 2.20-4.97).
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