Key result
In mice, mutant ANP induced arrhythmias in 62.5% of hearts during atrial pacing, whereas wild-type ANP completely prevented their occurrence.
Absolute Event Rate: 62.5% vs 0%
Mutant ANP promotes arrhythmogenesis by decreasing action potential upstroke velocity, duration, and L-type calcium currents via NPR-C, whereas wild-type ANP is antiarrhythmic.
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Mutant ANP may heighten arrhythmia risk; leaves open therapeutic targeting in human AF pending clinical studies.
Hua et al. (2015) studied Atrial fibrillation. Mutant form of atrial natriuretic peptide (mANP) vs. Wild-type ANP was evaluated on Arrhythmia induction during atrial pacing. In mice, mutant ANP induced arrhythmias in 62.5% of hearts during atrial pacing, whereas wild-type ANP completely prevented their occurrence.
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