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January 1, 1992Proceedings of the National Academy of SciencesOpen Access

Tolerance to a self-protein involves its immunodominant but does not involve its subdominant determinants.

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Authors

RCRicardo CibottiNational Institutes of HealthJKJean KanellopoulosCentre National de la Recherche ScientifiqueJCJean‐Pierre CabaniolsEgis (France)

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Cibotti et al. (1992) studied this question.

synapsesocial.com/papers/6a6f3ef878a11c550e08edd9https://doi.org/10.1073/pnas.89.1.416
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Transgenic Mouse Models of Self-Tolerance and Autoreactivity by the Immune System1990 · 38 citations
  2. 2T cell determinant structure: cores and determinant envelopes in three mouse major histocompatibility complex haplotypes.1991 · 133 citations
  3. 3Structural requirements for the interaction between peptide antigens and I-Ed molecules.1989 · 65 citations
  4. 4Working principles in the immune system implied by the "peptidic self" model.1987 · 111 citations
  5. 5A peripheral mechanism preserves self-tolerance to a secreted protein in transgenic mice.1990 · 39 citations