Why the study?
Does the M2 or M3 muscarinic acetylcholine receptor mediate vagally induced bradycardia and bronchoconstriction in mice?
Population
Mutant mice lacking M2 or M3 muscarinic acetylcholine receptors (M2-/- or M3-/- mice)
Design
Preclinical
Authors
Loading...
Distinguishes M2 from M3 mediation of vagal effects in mice; leaves open selective targeting for human vagal disorders.
Does the M2 or M3 muscarinic acetylcholine receptor mediate vagally induced bradycardia and bronchoconstriction in mice?
M2 receptors specifically mediate vagally induced bradycardia, while M3 receptors mediate bronchoconstriction, identifying distinct therapeutic targets for conditions involving altered vagal tone.
Fisher et al. (2004) studied this question.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: