Key result
Oral ethinylestradiol plus drospirenone significantly increased the aldosterone/renin ratio calculated by direct renin concentration (P<0.001), whereas subdermal etonogestrel had no effect.
Why the study?
Do oral ethinylestradiol plus drospirenone or subdermal etonogestrel affect the aldosterone/renin ratio used for primary aldosteronism screening in normotensive healthy women?
Population
32 normotensive, healthy women
Comparison
Oral ethinylestradiol plus drospirenone for 3… vs Baseline measurements (at menses)
Design
Cohort
Follow-up
Up to 6 weeks
Authors
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May warrant ARR caution with oral contraceptives using DRC; leaves open effects in hypertensive women needing prospective validation.
Do oral ethinylestradiol plus drospirenone or subdermal etonogestrel affect the aldosterone/renin ratio used for primary aldosteronism screening in normotensive healthy women?
Absolute Event Rate: 29.8% vs 6.6%
p-value: p=<0.001
Oral ethinylestradiol plus drospirenone can cause false-positive results in primary aldosteronism screening when using direct renin concentration to calculate the aldosterone/renin ratio, whereas subdermal etonogestrel does not.
Ahmed et al. (2011) studied Healthy (n=32). Oral ethinylestradiol plus drospirenone or subdermal etonogestrel vs. Baseline was evaluated on Aldosterone/renin ratio (ARR) calculated by direct renin concentration (DRC) (p=<0.001). Oral ethinylestradiol plus drospirenone significantly increased the aldosterone/renin ratio calculated by direct renin concentration (P<0.001), whereas subdermal etonogestrel had no effect.
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