Effect of Some Formulation Variables on the Entrapment Efficiency and in Vitro Release of Ketoprofen from Ketoprofen Niosomes

The objective of the present study was to formulate Ketoprofen Niosomes based on fixing the levels of different formulation variables which affect Niosomal preparation to study the effects of two formulation variables; changing the method of preparation by using either lipid hydration method or ether injection method, and changing the incorporated surfactant by using either Span 60 surfactant or mixed Span 60 surfactant with Tween grades surfactants (20, 40, 60, and 80 respectively) aiming of studying the effects of these variables on the entrapment efficiency and in vitro release of Ketoprofen from Ketoprofen Niosomes.