Formulation, In-vitro and In-vivo Evaluation of Semi-Interpenetrating Polymer Network (semi-IPN) Microspheres of Ketorolac Tromethamine

Ketorolac Tromethamine (KT) is freely soluble in water potent analgesic and moderately anti-inflammatory drug with a mean plasma half life of about 4 hours, was successfully encapsulated into (semi-IPN) microspheres, using (3 3 )full factorial design, which is An abbreviation of full factorial design of experiment, referring to experiment designs in statistics that are used to chart the output of processes that depend on two or more factors. A full factorial design includes all combinations of all possible values of the factors that affect the output of the process, and can be used to determine the combination of factors that produce the highest quality output. The objective of this work was to prepare different formulae of KT microspheres with gelatin and NaCMC (sodium carboxy methylcellulose) in different drug-polymer and polymer- polymer ratios. The capsules prepared from KT containing microspheres were subjected to in-vitro release study and the kinetic data was estimated. Accerlated stability testing was carried out on the selected KT formulae to study the degradation reaction and the expiry date (t90) was also calculated. The in-vivo evaluation of the anti-inflammatory and analgesic effects of KT in the chosen formulae, in comparison with the commercial tablet, Ketolac ® , were done