What question did this study set out to answer?

To determine whether bone marrow mesenchymal stem cell transplantation attenuates acute inflammation and promotes functional recovery by modulating macrophage activation following spinal cord injury.

January 10, 2012Journal of NeurotraumaOpen Access

Transplantation of Mesenchymal Stem Cells Promotes an Alternative Pathway of Macrophage Activation and Functional Recovery after Spinal Cord Injury

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Authors

HNHideaki NakajimaUniversity of Fukui KUKenzo UchidaUniversity of Fukui AGAlexander GuerreroUniversidad Técnica Particular de Loja

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Implication

Animal study demonstrates that mesenchymal stem cell therapy promotes M2 macrophage activation and locomotor recovery in rats with spinal cord injury, indicating reduced tissue scarring.

Key Points

To determine whether bone marrow mesenchymal stem cell transplantation attenuates acute inflammation and promotes functional recovery by modulating macrophage activation following spinal cord injury.
Induced spinal cord contusion injuries at T9-T10 in a rat model.
Administered 1.0×10^6 PKH26-labeled bone marrow mesenchymal stem cells directly into the injury epicenter 3 days post-injury.
Transplanted mesenchymal stem cells migrated without neural or glial differentiation, significantly increasing IL-4 and IL-13 levels while reducing TNF-α and IL-6 levels.
MSC transplantation shifted macrophage polarization, increasing alternatively activated M2 macrophages (arginase-1- or CD206-positive) and decreasing classically activated M1 macrophages (iNOS- or CD16/32-positive).
Treated rats achieved functional locomotion recovery that correlated with preserved axons, reduced glial scar formation, and increased myelin sparing.

Cite This Study

Nakajima et al. (2012) studied this question.

synapsesocial.com/papers/6a6f43b3e71d69abee07ee5a https://doi.org/10.1089/neu.2011.2109

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Implication

Animal study demonstrates that mesenchymal stem cell therapy promotes M2 macrophage activation and locomotor recovery in rats with spinal cord injury, indicating reduced tissue scarring.

Transplantation of Mesenchymal Stem Cells Promotes an Alternative Pathway of Macrophage Activation and Functional Recovery after Spinal Cord Injury

Discussion

Member takes

Implication

Key Points

Cite This Study

Transplantation of Mesenchymal Stem Cells Promotes an Alternative Pathway of Macrophage Activation and Functional Recovery after Spinal Cord Injury

Discussion

Member takes

Implication

Key Points

Cite This Study

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