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January 1, 1997Human Gene Therapy

Aerosol Administration of a Recombinant Adenovirus Expressing CFTR to Cystic Fibrosis Patients: A Phase I Clinical Trial

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Authors

GBG. BellonUniversité Claude Bernard Lyon 1LMLaurence Michel‐CalemardUniversité Claude Bernard Lyon 1DTDanièle Thouvenot

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Bellon et al. (1997) studied this question.

synapsesocial.com/papers/6a6f44fe31a3df824327ae4bhttps://doi.org/10.1089/hum.1997.8.1-15
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Modification of Nasal Epithelial Potential Differences of Individuals with Cystic Fibrosis Consequent to Local Administration of a Normal CFTR cDNA Adenovirus Gene Transfer Vector1995 · 135 citations
  2. 2Airway and lung elastic fibre is not reduced in asthma nor in asthmatics following corticosteroid treatment1995 · 41 citations
  3. 3Intrathecal Gene Therapy for the Treatment of Leptomeningeal Carcinomatosis. National Institutes of Health, Bethesda, Maryland1995 · 37 citations
  4. 4The cystic fibrosis gene has a “housekeeping”-type promoter and is expressed at low levels in cells of epithelial origin1991 · 177 citations
  5. 5In Vivo Nasal Potential Difference: Techniques and Protocols for Assessing Efficacy of Gene Transfer in Cystic Fibrosis1995 · 310 citations