This study identifies a critical oxygen delivery threshold of 300 ml/min/m2 immediately after cardiopulmonary bypass, below which oxygen uptake becomes supply-dependent, with differing dynamics based on blood lactate levels.
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May warrant attention to Do2 thresholds post-bypass stratified by lactate; leaves open whether targeted optimization improves outcomes in trials.
Komatsu et al. (1987) studied this question.
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