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April 21, 1995Science

Initiation of Protein Synthesis by the Eukaryotic Translational Apparatus on Circular RNAs

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Population

Eukaryotic translational apparatus and circular RNAs

Design

Preclinical

Authors

CCChangyou ChenChinese Academy of SciencesPSPeter SarnowStanford University

Discussion

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Implication

Challenges the 5' cap scanning model; leaves open physiological relevance and therapeutic translation in eukaryotes.

Structured PICO

P
Population
Eukaryotic translational apparatus and circular RNAs
I
Intervention
Circular RNAs containing internal ribosome entry site elements
O
Outcome
Initiation of translation and synthesis of polypeptide chains

Demonstrates that eukaryotic ribosomes can initiate translation on circular RNAs via internal ribosome entry sites, challenging the strict 5' end scanning model.

Cite This Study

Chen et al. (1995) studied this question.

synapsesocial.com/papers/6a6f459b439bab0cabc2bcd9https://doi.org/10.1126/science.7536344
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Internal ribosome entry site within hepatitis C virus RNA1992 · 925 citations
  2. 2In vitro mutational analysis of cis-acting RNA translational elements within the poliovirus type 2 5' untranslated region1991 · 97 citations
  3. 3A segment of the 5' nontranslated region of encephalomyocarditis virus RNA directs internal entry of ribosomes during in vitro translation1988 · 1,378 citations
  4. 4Terminal 7-methyl-guanosine cap structure on the normally uncapped 5' noncoding region of poliovirus mRNA inhibits its translation in mammalian cells1991 · 20 citations
  5. 5La autoantigen enhances and corrects aberrant translation of poliovirus RNA in reticulocyte lysate1993 · 498 citations