Key result
Elevated copeptin levels on admission were significantly higher in nonsurvivors compared with survivors (171.5 pM vs 86.8 pM; P=0.01) and independently predicted outcome (P=0.03).
Why the study?
Is plasma copeptin concentration elevated in hemorrhagic and septic shock, and does it predict survival in critically ill patients?
Observational (n=101)
No
Is plasma copeptin concentration elevated in hemorrhagic and septic shock, and does it predict survival in critically ill patients?
p-value: p=0.03
Copeptin is significantly elevated in hemorrhagic and septic shock and serves as an independent prognostic marker for survival in critically ill patients.
No takes yet. Share an insight, caveat, or question.
May aid prognostication in shock; leaves open incremental value and requires prospective validation before clinical use.
Morgenthaler et al. (2007) conducted an observational in Critically ill (sepsis, septic shock) (n=101). Elevated copeptin levels vs. Lower copeptin levels / healthy controls was evaluated on Survival / outcome (p=0.03). Elevated copeptin levels on admission were significantly higher in nonsurvivors compared with survivors (171.5 pM vs 86.8 pM; P=0.01) and independently predicted outcome (P=0.03).
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