Why the study?
Do selective beta-1 adrenoceptor antagonists (Practolol, UK 6558, M&B 17,803A) alter chronotropic, inotropic, and vasodilator responses to isoprenaline in normal human volunteers?
Do selective beta-1 adrenoceptor antagonists (Practolol, UK 6558, M&B 17,803A) alter chronotropic, inotropic, and vasodilator responses to isoprenaline in normal human volunteers?
Practolol and UK 6558 demonstrate selective cardiac beta-1 adrenoceptor antagonism in normal human volunteers.
Supports selective cardiac beta-1 antagonism in volunteers; leaves open translation to patient care or practice change.
Selective antagonism of the cardiac beta(1)-adrenoceptors has been studied in normal human volunteers.2. Practolol and UK 6558 produced greater antagonism of the chronotropic and inotropic responses to i.v. isoprenaline than of the vasodilator response to either i.v. or intra-arterial isoprenaline. A third drug, M&B 17,803A, produced non-selective beta-adrenoceptor blockade in 2 of 3 subjects studied.3. Practolol, UK 6558 and M&B 17,803A, produced an attenuation of the responses to Valsalva's manoeuvre.4. A substantial reduction in blood pressure was seen in 3 of 4 normotensive subjects given UK 6558.
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Briant et al. (1973) studied this question.
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