Prognostic Factors of Retroperitoneal Soft-Tissue Sarcomas

Retroperitoneal soft-tissue sarcomas are rare malignant tumors and make up 1% of all adult malignancies. We aimed to evaluate the morbidity, the mortality, and the prognostic factors that affect survival of the patients with retroperitoneal soft-tissue sarcoma in this study. Patients and Methods: 27 adult patients with retroperitoneal soft-tissue sarcoma underwent surgery between 1992 and 2005 in our clinic. Long-term survival and the independent prognostic factors that affect survival, e.g. age, gender, type of resection (complete resection, partial resection, or only laparotomy and biopsy), site of the tumor, invasion to adjacent organs, tumor size, type of tumor histology, histologic grading, stage of the tumor, and adjuvant radiochemotherapy application, were evaluated. Results: Overall survival rate was 58.1% at 1 year, 58.1% at 3 years, and 32.3% at 5 years. Resection type (p = 0.002), grade (p = 0.011), and stage (p = 0.005) were the prognostic features identified by univariate analysis. Among the significant prognostic factors in the univariate analysis, only two factors, surgical resection (p = 0.011, hazard ratio = 15.570) and tumor grade (p = 0.002, hazard ratio = 12.491), proved to be independently significant in the multivariate analysis. Conclusion: The completeness of resection and tumor grade significantly influence overall survival in this tumor entity.