What question did this study set out to answer?

To investigate the antidepressant effects of Acanthopanax senticosus and determine its underlying molecular and metabolic mechanisms in major depressive disorder.

August 5, 2022Frontiers in Cell and Developmental BiologyOpen Access

Integrated network pharmacology and hepatic metabolomics to reveal the mechanism of Acanthopanax senticosus against major depressive disorder

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Authors

XGXinyi GuNanjing Agricultural University GZGuanying ZhangCzech Academy of Sciences, Institute of Biotechnology QWQixue WangTianjin Medical University General Hospital

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Implication

Preclinical study reveals Acanthopanax senticosus modulates amino acid and carbohydrate metabolism in depressed mice, indicating multi-target therapeutic pathways against major depressive disorder.

Key Points

To investigate the antidepressant effects of Acanthopanax senticosus and determine its underlying molecular and metabolic mechanisms in major depressive disorder.
Administered Acanthopanax senticosus orally at dosages of 100, 200, and 400 mg/kg daily for 6 weeks to chronic unpredictable mild stress (CUMS) mouse models.
Conducted gas chromatography–mass spectrometry (GC–MS) hepatic metabolomics alongside network pharmacology compound-target prediction.
Verified binding affinities between prioritized target proteins and active herbal compounds via molecular docking simulations.
Hepatic metabolomics revealed 13 differential metabolites and four distinct altered metabolic pathways following treatment.
Integrated network analysis identified six overlapping core targets (DAO, MAOA, MAOB, GAA, HK1, and PYGM) primarily governing glycine, serine, and threonine metabolism, as well as starch and sucrose metabolism.
Molecular docking demonstrated favorable binding interactions between all six targets and herbal compounds including isofraxidin, eleutheroside B1, eleutheroside C, quercetin, kaempferol, and acacetin.

Cite This Study

Gu et al. (2022) studied this question.

synapsesocial.com/papers/6a6f477f5d37378ac1dc5a74 https://doi.org/10.3389/fcell.2022.900637

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Implication

Preclinical study reveals Acanthopanax senticosus modulates amino acid and carbohydrate metabolism in depressed mice, indicating multi-target therapeutic pathways against major depressive disorder.

Integrated network pharmacology and hepatic metabolomics to reveal the mechanism of Acanthopanax senticosus against major depressive disorder

Discussion

Member takes

Implication

Key Points

Cite This Study

Integrated network pharmacology and hepatic metabolomics to reveal the mechanism of Acanthopanax senticosus against major depressive disorder

Discussion

Member takes

Implication

Key Points

Cite This Study

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