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March 17, 2020Science SignalingOpen Access

PTPN22 phosphorylation acts as a molecular rheostat for the inhibition of TCR signaling

Shen K. Yang Mattias N. D. Svensson Nathaniel H. O. Harder Wan‐Chen Hsieh Eugenio Santelli William B. Kiosses James J. Moresco John R. Yates Charles C. King Lin Liu Stephanie M. Stanford Nunzio Bottini

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Abstract

mediates a reciprocal regulation of PTPN22 stability versus translocation to TCR signaling complexes by CSK-dependent and CSK-independent mechanisms.

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Yang et al. (2020) studied this question.

synapsesocial.com/papers/6a6f478735aa2c282ce0aac7 https://doi.org/10.1126/scisignal.aaw8130

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Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

1Tyrosine Phosphatase PTPN22: Multifunctional Regulator of Immune Signaling, Development, and DiseaseOriginal Research · 2013 · 232 citations
2PEST Domain-Enriched Tyrosine Phosphatase (PEP) Regulation of Effector/Memory T CellsOriginal Research · 2004 · 379 citations
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5Autoimmune-associated PTPN22 R620W Variation Reduces Phosphorylation of Lymphoid Phosphatase on an Inhibitory Tyrosine ResidueOriginal Research · 2010 · 98 citations

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