What question did this study set out to answer?

To determine cerebral responses to bladder filling in individuals with normal bladder control compared to those with detrusor overactivity.

October 7, 2005The Journal of Urology

Brain Control of Normal and Overactive Bladder

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Authors

DGDerek GriffithsUniversity of Pittsburgh SDStuart DerbyshireNational University of Singapore ASAndy StengerUniversity of Hawaiʻi at Mānoa

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Implication

Functional MRI study reveals deficient orbitofrontal cortex activation during bladder filling in adults with overactive bladder, indicating a central neurophysiological basis for poor control.

Key Points

To determine cerebral responses to bladder filling in individuals with normal bladder control compared to those with detrusor overactivity.
Conducted functional magnetic resonance imaging (fMRI) in 12 adults (1 male, 11 females; aged 26–83 years) without overt neurological abnormality, categorized as having good (N=6) or poor (N=6) bladder control based on prior urodynamics.
Measured cerebral activity and intravesical pressure during repeated infusion and withdrawal of liquid into the bladder at both small and large bladder volumes.
Bladder filling provoked widespread activation in regions including the periaqueductal gray, thalamus, insula, dorsal anterior cingulate, and ventromedial cerebellum, with responses intensifying at large bladder volumes.
Individuals with normal bladder control showed prominent response strengthening in the orbitofrontal cortex as bladder volume increased.
Participants with poor bladder control exhibited exaggerated cortical activation at larger volumes, yet the orbitofrontal cortex remained weakly activated regardless of concurrent detrusor activity.

Cite This Study

Griffiths et al. (2005) studied this question.

synapsesocial.com/papers/6a6f47c478a11c550e08f75e https://doi.org/10.1097/01.ju.0000177450.34451.97

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Implication

Functional MRI study reveals deficient orbitofrontal cortex activation during bladder filling in adults with overactive bladder, indicating a central neurophysiological basis for poor control.

Brain Control of Normal and Overactive Bladder

Discussion

Member takes

Implication

Key Points

Cite This Study

Brain Control of Normal and Overactive Bladder

Discussion

Member takes

Implication

Key Points

Cite This Study

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