Key result
Doxorubicin treatment (20 or 30 mg/kg) induced significant QTc and RR interval prolongation in anesthetized but not conscious female mice, demonstrating anesthesia and sex-dependent cardiotoxicity.
Why the study?
Doxorubicin causes significant cardiotoxicity, but its effects on cardiac electrophysiology in conscious versus anesthetized states needed investigation.
Does doxorubicin alter cardiac electrophysiology differently in conscious versus anesthetized mice?
Population
Male and female C57BL/6 mice
Comparison
Saline vs 20 mg/kg DOX vs 30 mg/kg DOX
Design
Preclinical animal study
Follow-up
5 days
Authors
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Anesthesia and female sex amplify acute DOX ECG changes in mice; hypothesis-generating for sex- and state-specific cardiotoxicity monitoring.
Does doxorubicin alter cardiac electrophysiology differently in conscious versus anesthetized mice?
The electrocardiographic response to doxorubicin in mice is significantly modulated by anesthesia and sex, highlighting important methodological considerations for preclinical cardiotoxicity models.
Warhol et al. (2021) studied Doxorubicin cardiotoxicity. Doxorubicin vs. Saline was evaluated on ECG parameters (P, PR, QRS, QTc, and RR intervals) and heart rate variability. Doxorubicin treatment (20 or 30 mg/kg) induced significant QTc and RR interval prolongation in anesthetized but not conscious female mice, demonstrating anesthesia and sex-dependent cardiotoxicity.
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