Key result
Lipopolysaccharide-induced endotoxemia decreased heart rate variability spectral activity in the high-frequency range compared to saline controls.
In a rat model of LPS-induced endotoxemia, reduced high-frequency heart rate variability indicates decreased parasympathetic activity associated with increased cardiac IL-6 production.
Answers are grounded in this paper and cite their sources.
Suggests vagal withdrawal in endotoxemia; hypothesis-generating and leaves open clinical relevance in human sepsis.
The aim of the study was to evaluate short-term heart rate variability (HRV) as an index of cardiac autonomic control in rats with lipopolysaccharide (LPS)-induced endotoxemia. Animals were injected intraperitoneally with LPS (100 microg/kg b.w.) and control group with an equivalent volume of saline. ECG recordings were done before (base) and 60, 120, 180, 240 and 300 min after LPS or saline administration. HRV magnitude was quantified by time and frequency-domain analysis (mean RR interval, SDRR, RMSSD, spectral powers in low (LF) and high frequency (HF) bands. Heart tissue homogenates and plasma were analyzed to determine interleukin 6 (IL-6), tumor necrosis factor alpha (TNF-alpha) and oxidative stress level (TBARS). Administration of lipopolysaccharide was followed by continuous rise in colonic body temperature compared to saline-treated controls. Endotoxemia in rats was accompanied by significant decrease in HRV spectral activity in high-frequency range at maximal body temperature (logHFpower: 1.2+/-0.5 vs. 1.9+/-0.6 ms(2), P<0.01). Increased IL-6 was found in heart tissue homogenates of LPS rats (8.0+/-0.6 vs. 26.4+/-4.8 pg/ml, (P<0.05). In conclusions, reduced HRV in HF band may indicate a decreased parasympathetic activity in LPS-induced endotoxemia as basic characteristics of altered cardiac control during response to endotoxemia.
No takes yet. Share an insight, caveat, or question.
Žila et al. (2015) studied Lipopolysaccharide-induced endotoxemia (n=28). Lipopolysaccharide (LPS) vs. Sterile saline was evaluated on Heart rate variability spectral activity in high-frequency range (logHFpower) at maximal body temperature (p=<0.01). Lipopolysaccharide-induced endotoxemia decreased heart rate variability spectral activity in the high-frequency range compared to saline controls.
Synapse has enriched 10 related papers. Consider them for comparative context: