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August 1, 2003International Journal of Molecular Medicine

Regulatory effect of regucalcin on nitric oxide synthase activity in rat kidney cortex cytosol: Role of endogenous regucalcin in transgenic rats

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Key result

No clinical data is present in the provided text, which is a library recommendation form.

Population

Rat kidney cortex cytosol (wild-type and regucalcin transgenic rats overexpressing endogenous regucalcin)

Comparison

Regucalcin (exogenous addition 10-10 M, or… vs Absence of regucalcin or wild-type rats

Design

Preclinical

Authors

MZMa ZhongHuaiyin Normal UniversityMYMasayoshi YamaguchiUniversity of Hawaiʻi at Mānoa

Discussion

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Implication

Animal data on regucalcin suppressing renal NOS activity; leaves open any human relevance or therapeutic role.

Structured PICO

P
Population
Rat kidney cortex cytosol (wild-type and regucalcin transgenic rats overexpressing endogenous regucalcin)
I
Intervention
Regucalcin (exogenous addition 10(-10)-10(-8) M, or endogenous overexpression in transgenic rats)
C
Comparator
Absence of regucalcin or wild-type rats
O
Outcome
Nitric oxide (NO) synthase activitysurrogate

Regucalcin suppresses calcium/calmodulin-dependent nitric oxide synthase activity in rat kidney cortex.

Cite This Study

Zhong et al. (2003) studied this question. No clinical data is present in the provided text, which is a library recommendation form.

synapsesocial.com/papers/6a6f48c735aa2c282ce0abe0https://doi.org/10.3892/ijmm.12.2.201
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