Key result
Extracellular vesicles and their associated micro-RNAs play crucial roles in the progression of liver diseases, offering potential as novel biomarkers and therapeutic targets.
EV-associated miRNAs play crucial roles in intercellular communication during liver disease progression and hold potential as novel non-invasive biomarkers and therapeutic targets.
EV-miRNA signaling drives liver disease progression via hepatocyte-to-cell transfer; extends mechanistic models but leaves open targeted therapies.
Progression of liver disease is dependent on intercellular signaling, including those mediated by extracellular vesicles (EVs). Within these EVs, microRNAs (miRNAs) are packaged to selectively silence gene expression in recipient cells for upregulating or downregulating a specific pathway. Injured hepatocytes secrete EV-associated miRNAs which can be taken up by liver sinusoidal endothelial cells, immune cells, hepatic stellate cells, and other cell types. In addition, these recipient cells will secrete their own EV-associated miRNAs to propagate a response throughout the tissue and the circulation. In this review, we comment on the implications of EV-miRNAs in the progression of alcohol-associated liver disease, metabolic dysfunction-associated steatohepatitis, viral and parasitic infections, liver fibrosis, and liver malignancies. We summarize how circulating miRNAs can be used as biomarkers and the potential of utilizing EVs and miRNAs as therapeutic methods to treat liver disease.
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Washington et al. (2024) conducted a review in Liver Disease. Extracellular Vesicles and Micro-RNAs was evaluated. Extracellular vesicles and their associated micro-RNAs play crucial roles in the progression of liver diseases, offering potential as novel biomarkers and therapeutic targets.
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