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Eight volunteers smoked marihuana cigarettes under controlled laboratory conditions on 4 separate occasions. The cigarettes were calibrated to deliver doses of 0, 3, 6, and 9 µg per kilogram of delta‐9‐tetrahydrocannabinol (THC). The experimental design was a double‐blind random block with a 1 week interval between sessions. Analysis of variance revealed a significant linear decrease in stability with increase in dose of THC. The tracking scores with Pursuit Meter (PM) demonstrated a significant increase above control for all three doses of THC. Mental performance, as evaluated by Delayed Auditory Feedback (DAF), and subjective evaluation revealed no consistent change with dose.
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Evans et al. (1973) studied this question.
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