What question did this study set out to answer?

To investigate the relationship between nuclear SREBP-1c levels and hepatic steatosis in mouse models of diabetes.

Increased Levels of Nuclear SREBP-1c Associated with Fatty Livers in Two Mouse Models of Diabetes Mellitus

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To investigate the relationship between nuclear SREBP-1c levels and hepatic steatosis in mouse models of diabetes.
Measured nuclear SREBP-1c protein levels in liver samples from ob/ob and aP2-SREBP-1c mice.
Analyzed mRNA levels of SREBP target genes involved in fatty acid biosynthesis.
Compared results with wild-type mouse controls.
Nuclear SREBP-1c levels were significantly higher in ob/ob and aP2-SREBP-1c mice compared to wild-type (p<0.05).
Elevated mRNA levels for SREBP target genes were observed in diabetic mice, indicating increased fatty acid synthesis.
Increased nuclear SREBP-1c was associated with higher rates of hepatic fatty acid synthesis in vivo.

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Preclinical mouse data should not change clinical NAFLD management; leaves open SREBP-1c causality in human diabetic steatosis.

Shimomura et al. (1999) studied this question.

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