Cutaneous Reactions Due to Sulfamethoxypyridazine

Prlina et al. 1 and Grieble and Jackson 2 have reported on the clinical effectiveness of sulfamethoxypyridazine * (SMPZ) as an antibacterial agent in the treatment of urinary tract infections. Nichols et al. 3 , Foerster et al., 4 and Boger et al. 5 have investigated the pharmacology of this drug. SMPZ was considered useful because a single daily oral dose of 0.5 gm. produced and maintained effective antibiotic concentrations of free sulfonamide in the serum and urine against Escherichia coli. It was readily absorbed from the gastrointestinal tract and slowly excreted in the urine. It was found to have a low degree of acetylation and was more soluble in acid mediums than other sulfonamides. Its antibacterial effectiveness was found comparable to that of sulfadiazine. SMPZ shows some promise in the treatment of dermatitis herpetiformis. 6 We wish to report the occurrence of erythematous maculopapular dermatitis in patients