Key result
Multi-MUP analysis demonstrated high sensitivity for diagnosing myopathy in FSHD, detecting abnormalities in all weak biceps brachii muscles and in 77% of those with normal strength.
Why the study?
Does multi-MUP analysis have high sensitivity for diagnosing myopathy in patients with facioscapulohumeral muscular dystrophy?
Population
31 patients with a molecular genetic diagnosis of facioscapulohumeral muscular dystrophy (FSHD)
Design
Cross-sectional
Authors
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Suggests multi-MUP analysis may aid early FSHD myopathy detection; leaves open prospective validation before clinical use.
Cross-Sectional (n=31)
Does multi-MUP analysis have high sensitivity for diagnosing myopathy in patients with facioscapulohumeral muscular dystrophy?
Multi-MUP analysis demonstrates high sensitivity for detecting myopathic abnormalities in FSHD, even in muscles with normal strength.
Podnar et al. (2006) conducted a cross-sectional in Facioscapulohumeral muscular dystrophy (FSHD) (n=31). Multi-MUP analysis was evaluated on Sensitivity for diagnosing myopathy. Multi-MUP analysis demonstrated high sensitivity for diagnosing myopathy in FSHD, detecting abnormalities in all weak biceps brachii muscles and in 77% of those with normal strength.
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