Population
Planar lipid bilayer model
Comparison
VDAC and pro-apoptotic Bax interaction vs VDAC alone, Bax alone, or VDAC with…
Design
Preclinical
Authors
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Does not inform clinical practice; leaves open the in vivo role of this pore in cardiac apoptosis.
Provides direct electrophysiological evidence that VDAC and Bax form a novel large pore permeable to cytochrome c, elucidating a mechanism of apoptotic signal transduction.
Shimizu et al. (2000) studied this question.
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