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July 28, 2004Angewandte Chemie

Directed Evolution of Cyclohexanone Monooxygenases: Enantioselective Biocatalysts for the Oxidation of Prochiral Thioethers

Manfred T. Reetz Franck Daligault Birgit Brunner Heike Hinrichs Alfred Deege

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Abstract

Mutationen in Cyclohexanon-Monooxygenasen (CHMOs), beispielsweise die Einführung von Serin an Position 432, lieferten überraschend nützliche enantioselektive Biokatalysatoren, die sich besonders für die Luft-vermittelte partielle Oxidation prochiraler Thioether eignen (siehe Schema).

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Reetz et al. (2004) studied this question.

synapsesocial.com/papers/6a6f4ca631a3df824327b3fb https://doi.org/10.1002/ange.200460311

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