Experimental study demonstrates Sirtuin 3 loss alters mitochondrial metabolism and triggers death in infected macrophages, highlighting a mechanism of bacterial pathogenesis.
Tuberculosis, the disease caused by the bacterium M. tuberculosis , remains one of the top 10 causes of death worldwide. Macrophages, the first cells to encounter M. tuberculosis and critical for defense against infection, are hijacked by M. tuberculosis as a protected growth niche. M. tuberculosis -infected macrophages undergo metabolic reprogramming where key mitochondrial pathways are modulated, but the mechanisms driving this metabolic shift is unknown.
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Smulan et al. (2021) studied this question.
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