Key result
In ICU AMI patients, platelet count showed a U-shaped relationship with 30-day mortality; each 10x10⁹/L increase below 147x10⁹/L reduced risk (OR 0.931), while increases above raised it (OR 1.023).
Why the study?
Acute myocardial infarction remains a major global health challenge with high mortality, prompting investigation into the association between platelet count and 30-day in-hospital mortality in critically ill patients.
Cohort (n=6,850)
Yes
Odds Ratio: 0.931 (95% CI 0.892–0.973)
p-value: p=0.001
Baseline platelet count exhibits a U-shaped relationship with 30-day in-hospital mortality in critically ill AMI patients, with an optimal threshold around 147 × 10⁹/L, suggesting its utility as a risk stratification marker.
Baseline platelet count inversely associates with 30-day mortality in critically ill AMI; hypothesis-generating and requires prospective validation.
Acute myocardial infarction (AMI) remains a major global health challenge with high mortality rates. This study investigated the association between platelet count and 30-day in-hospital mortality in critically ill AMI patients. This multicenter retrospective cohort study analyzed 6,850 critically ill AMI patients from 208 U.S. hospitals (2014-2015) using the eICU Collaborative Research Database v2.0. The primary exposure was baseline platelet count within 24 h of ICU admission. The primary outcome was 30-day in-hospital mortality. Analyses were adjusted for demographics, laboratory parameters, disease severity, comorbidities, and treatments. A U-shaped relationship was identified between platelet count and mortality, with an inflection point at 147 × 10⁹/L. Below this threshold, each 10 × 10⁹/L increase in platelet count was associated with decreased mortality (OR = 0.931, 95% CI: 0.892-0.973, P = 0.001). Above the threshold, each 10 × 10⁹/L increase was associated with increased mortality (OR = 1.023, 95% CI: 1.010-1.036, P < 0.001). A U-shaped relationship was observed between platelet count and 30-day in-hospital mortality in critically ill AMI patients, with optimal outcomes observed at approximately 147 × 10⁹/L, suggesting that platelet count may serve as a potential risk stratification marker.
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Tao et al. (2025) conducted a cohort in Acute myocardial infarction (n=6,850). Baseline platelet count was evaluated on 30-day in-hospital mortality (OR 0.931, 95% CI 0.892-0.973, p=0.001). In ICU AMI patients, platelet count showed a U-shaped relationship with 30-day mortality; each 10x10⁹/L increase below 147x10⁹/L reduced risk (OR 0.931), while increases above raised it (OR 1.023).
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