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June 1, 1979The Journal of Cell BiologyOpen Access

Reversible alteration in the neuromuscular junctions of Drosophila melanogaster bearing a temperature-sensitive mutation, shibire.

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Population

Drosophila melanogaster bearing a temperature-sensitive mutation, shibire

Comparison

Temperature elevation to ≥29°C, with or without… vs Baseline temperature (22°C) or no prior treatment

Design

Preclinical

Authors

CPClifton A. PoodryUniversity of OregonLELaurienne EdgarEli Lilly (United States)

Discussion

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Implication

Indicates activity-dependent vesicle depletion in shibire paralysis; hypothesis-generating for synaptic mechanisms, should not change practice.

Structured PICO

P
Population
Drosophila melanogaster bearing a temperature-sensitive mutation, shibire
I
Intervention
Temperature elevation to ≥29°C, with or without prior treatment with tetrodotoxin or barbiturate
C
Comparator
Baseline temperature (22°C) or no prior treatment
O
Outcome
Number of synaptic vesicles in neuromuscular junctions of tibial musclessurrogate

Temperature-induced paralysis in shibire mutant Drosophila is associated with a reversible depletion of synaptic vesicles that is prevented by tetrodotoxin or barbiturates.

Cite This Study

Poodry et al. (1979) studied this question.

synapsesocial.com/papers/6a6f4f8e35aa2c282ce0b16ahttps://doi.org/10.1083/jcb.81.3.520
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1THE USE OF LEAD CITRATE AT HIGH pH AS AN ELECTRON-OPAQUE STAIN IN ELECTRON MICROSCOPY1963 · 25,086 citations
  2. 2Temperature-Sensitive Mutations in <i>Drosophila melanogaster</i> , VII. A Mutation ( <i> para <sup>ts</sup> </i> ) Causing Reversible Adult Paralysis1971 · 239 citations
  3. 3Neurophysiological defects in temperature-sensitive paralytic mutants of Drosophila melanogaster.1976 · 244 citations
  4. 4EVIDENCE FOR RECYCLING OF SYNAPTIC VESICLE MEMBRANE DURING TRANSMITTER RELEASE AT THE FROG NEUROMUSCULAR JUNCTION1973 · 2,163 citations
  5. 5The Effects of Increased Temperature on Electroretinograms of Temperature-Sensitive Paralysis Mutants of <i>Drosophila melanogaster</i>1974 · 38 citations