Effects of early removal of the heart and arrest of the circulation on the development of frog embryos

This study was first undertaken to test tlic action of solutions o f acetone-chloroform, a specific heart poison, in suppressing the circulation from the earliest possible stage of frog embryos, especially with eggs of 13.Palustris and R. Sylvatica.Loeb made some similar experiments in 1893 with solutions of potassium chloride (KC1) acting on the eggs of a fish (Fundulus), b u t based his conclusions on living embryos only, without comparing them with prcserved material and sections.