Key result
Bioinformatics analysis identified 16 cellular senescence-related genes in calcific aortic valve disease and highlighted β-Carotene as a potential therapeutic agent interacting with MMP9, MEIS2, and CTSB.
Why the study?
Calcific aortic valve disease is a progressive, age-related degenerative disease, and identifying key genes associated with cellular senescence in CAVD was needed.
Bioinformatics analysis identified key cellular senescence-related genes in calcified aortic valve disease and highlighted beta-carotene as a potential therapeutic agent.
Answers are grounded in this paper and cite their sources.
CS-DEGs identified in CAVD; hypothesis-generating and leaves open validation or therapeutic targeting.
OBJECTIVE: Calcific aortic valve disease (CAVD) is a progressive, age-related degenerative disease characterized by the accumulation of calcium deposits in the aortic valve. We aim to screen key genes associated with cellular senescence (CS) in CAVD. METHODS: The GSE12644 and GSE51472 datasets from the GEO database was utilized in this study, and differentially expressed genes (DEGs) were identified using the "limma" R package. CS-related DEGs (CS-DEGs) were determined through the CellAge database. Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) enrichment analyses were performed on CS-DEGs. A protein-protein interaction (PPI) network was constructed using the STRING database. The cytoHubba plug-in in Cytoscape was used to identify hub genes. A noncoding-RNA-mRNA regulatory network was established. DSigDB database was used to to identify drugs potentially be useful for treating CAVD. RESULTS: A total of 16 CS-DEGs were identified. These genes were primarily associated with collagen metabolic process, collagen catabolic process and external side of plasma membrane. 10 hub genes were identified as regulators of cellular senescence in CAVD: LPAR1, PTPN6, CD28, ID1, MEIS2, FGFR3, KDR, MMP7, AR, HIF1A. The Noncoding RNA-mRNA regulatory network indicated that CS-DEGs may be regulated by noncoding RNAs. β-Carotene, a naturally occurring carotenoid with antioxidant properties, was identified potential therapeutic agents through interacting with MMP9, MEIS2, and CTSB. CONCLUSION: This study provides insights into the key genes and pathways related to cellular senescence in CAVD (MMP9, MEIS2, and CTSB) and highlights the potential role of β-Carotene treatment of CAVD.
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Tao et al. (2025) studied Calcific aortic valve disease (CAVD). β-Carotene was evaluated on Identification of cellular senescence-related differentially expressed genes (CS-DEGs) and potential therapeutic agents. Bioinformatics analysis identified 16 cellular senescence-related genes in calcific aortic valve disease and highlighted β-Carotene as a potential therapeutic agent interacting with MMP9, MEIS2, and CTSB.
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