Key result
Faster heart rates increased repolarization heterogeneity, with TWR at 550 vs 1150 ms being 0.29% vs 0.08% in women (P=2x10^-8) and 0.14% vs 0.04% in men (P=2x10^-15).
Why the study?
Does heart rate affect global and regional repolarization heterogeneity (TCRT and TWR) in healthy subjects?
Population
60 healthy subjects (27 males)
Design
Cohort
Follow-up
24 hours
Authors
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No immediate change to rate-control practices warranted; leaves open contribution to arrhythmic risk in patients.
Observational (n=60)
Does heart rate affect global and regional repolarization heterogeneity (TCRT and TWR) in healthy subjects?
Global and regional repolarization heterogeneity increase at faster heart rates, with women exhibiting greater heterogeneity than men.
Smetana et al. (2004) conducted an observational in Healthy subjects (n=60). Shorter RR intervals (faster heart rate) vs. Longer RR intervals (slower heart rate) was evaluated on Total cosine of the QRS-T angle (TCRT) and relative T wave residuum (TWR). Faster heart rates increased repolarization heterogeneity, with TWR at 550 vs 1150 ms being 0.29% vs 0.08% in women (P=2x10^-8) and 0.14% vs 0.04% in men (P=2x10^-15).
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