Key result
Manipulation of the brain renin-angiotensin system with angiotensin receptor blockers or ACE inhibitors may constitute an effective neuroprotective strategy against dopaminergic vulnerability and progression of Parkinson's disease.
The brain renin-angiotensin system plays a major role in dopaminergic vulnerability, and its manipulation may offer neuroprotection in Parkinson's disease.
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Hypothesis-generating for RAS modulators in PD neuroprotection; does not support practice change without RCTs.
Labandeira‐García et al. (2014) conducted a review in Parkinson's disease and dopaminergic cell vulnerability. Angiotensin receptor blockers and ACE inhibitors was evaluated. Manipulation of the brain renin-angiotensin system with angiotensin receptor blockers or ACE inhibitors may constitute an effective neuroprotective strategy against dopaminergic vulnerability and progression of Parkinson's disease.
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