Key result
Mediastinal radiotherapy was associated with a 6.8-fold increased risk of coronary artery abnormalities compared to no mediastinal radiotherapy in childhood Hodgkin's lymphoma survivors (P=0.009).
Why the study?
Does computed tomography angiography detect coronary artery abnormalities in survivors of childhood Hodgkin's lymphoma?
Population
119 survivors of childhood Hodgkin's lymphoma who have been treated with radiotherapy and/or cardiotoxic…
Design
Cross-sectional
Authors
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May support targeted CTA evaluation after mediastinal radiotherapy; leaves open whether screening improves long-term outcomes.
Observational (n=119)
Does computed tomography angiography detect coronary artery abnormalities in survivors of childhood Hodgkin's lymphoma?
Relative Risk: 6.8
p-value: p=0.009
Coronary CTA is an effective, minimally invasive tool for the early diagnosis of coronary artery disease in survivors of childhood Hodgkin's lymphoma, particularly those treated with mediastinal radiotherapy.
Küpeli et al. (2009) conducted an observational in Childhood Hodgkin's lymphoma (n=119). Mediastinal radiotherapy vs. No mediastinal radiotherapy was evaluated on Coronary artery abnormalities (6.8 times increased risk, p=0.009). Mediastinal radiotherapy was associated with a 6.8-fold increased risk of coronary artery abnormalities compared to no mediastinal radiotherapy in childhood Hodgkin's lymphoma survivors (P=0.009).
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