Key result
In an experimental in vitro model, increasing arterial stenosis severity and pulse rate significantly increased the pressure drop and the power consumed by the peristaltic pump.
Why the study?
Blood and vessel interactions and consequent hemodynamic effects cause cardiovascular diseases, prompting investigation into the hemodynamic impact of arterial stenosis severity.
Does increased pulse rate and stenosis severity increase pressure drop and pump power consumption in an in vitro arterial model?
Does increased pulse rate and stenosis severity increase pressure drop and pump power consumption in an in vitro arterial model?
In an in vitro model, increased arterial stenosis severity and simulated pulse rate significantly increased pressure drop and pump power consumption, highlighting the hemodynamic burden of high-exertion activities in severe stenosis.
Peristaltic pump model may aid in vitro hemodynamic testing; leaves open clinical translation of pressure and power findings.
Biomedical studies is among the multidisciplinary studies attracting most interest in recent years. Blood and vessel interactions and consequent hemodynamic effects cause cardiovascular diseases. A testing setup constituted by a peristaltic pump (similar to the heart mechanism) system was installed. The purpose of the experimental study presented is to investigate the effect, pressure drop, peristaltic pump inlet and outlet pressure and most importantly, the amount of power consumed by the peristaltic pump regarding arterial stenosis severity with varying areal stenosis percentages. The tests were performed for the pulse values from 54 to 168 bpm by setting up models with 0%, 60%, 70% and 80% symmetrical stenosis severities. In the study, the pressure difference in the test area increased concomitantly with elevated pulse value and increased stenosis severity. This situation revealed that as the intensity of narrowing increases in vessels, the narrowing space differential pressure increases, and this amount increases even more with increased exertion. The pressure at the peristaltic pump outlet increased concomitantly with elevated pulse value and increased stenosis severity. The peristaltic pump overworked to overcome the increased differential pressure related to the increased pulse value and stenosis severity. This result of the experimental data reveals the necessity to avoid activities requiring high pulse in human arteries similarly with a high percentage of stenosis.
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Sonmez et al. (2021) studied Arterial stenosis (in vitro model). Symmetrical stenosis models (60%, 70%, 80%) and varying pulse rates vs. 0% stenosis (healthy artery model) was evaluated on Pressure drop and pump power consumption. In an experimental in vitro model, increasing arterial stenosis severity and pulse rate significantly increased the pressure drop and the power consumed by the peristaltic pump.
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