What question did this study set out to answer?

To evaluate the role of HER2/neu protein overexpression and gene amplification in the progression of ductal carcinoma in situ to invasive breast carcinoma.

December 1, 2002Modern PathologyOpen Access

The Role of HER2/neu Overexpression/Amplification in the Progression of Ductal Carcinoma In Situ to Invasive Carcinoma of the Breast

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Authors

ELEleanor LattaUniversity of Toronto STSuzanna TjanMount Sinai Hospital RPRobert ParkesNorfolk and Norwich University Hospital

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Implication

Retrospective pathology study reveals lower HER2/neu overexpression in invasive breast cancer than in ductal carcinoma in situ, suggesting it does not drive progression to invasive disease.

Key Points

To evaluate the role of HER2/neu protein overexpression and gene amplification in the progression of ductal carcinoma in situ to invasive breast carcinoma.
Retrospectively analyzed 251 breast tumor cases (91 pure ductal carcinoma in situ, 136 invasive ductal carcinomas with associated in situ disease, and 24 pure invasive carcinomas) stained with CB11 and TAB250 monoclonal antibodies.
Evaluated gene amplification on 33 representative tumor specimens using fluorescence in situ hybridization.
HER2/neu protein overexpression occurred in 34% of pure ductal carcinoma in situ cases, 17% of invasive cases with associated in situ disease, and 12.5% of pure invasive carcinomas (P = .01).
In high-grade lesions, overexpression was present in 60% of pure in situ cases versus 29% of invasive cases with associated in situ disease and 22% of pure invasive carcinomas (P = .02).
Concordance between in situ and invasive components of individual tumors reached 90% by immunohistochemistry, and concordance between immunohistochemistry and gene amplification was 91% in 33 evaluated cases.

Cite This Study

Latta et al. (2002) studied this question.

synapsesocial.com/papers/6a6f550b78a11c550e0905f0 https://doi.org/10.1097/01.mp.0000038462.62634.b1

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Implication

Retrospective pathology study reveals lower HER2/neu overexpression in invasive breast cancer than in ductal carcinoma in situ, suggesting it does not drive progression to invasive disease.

The Role of HER2/neu Overexpression/Amplification in the Progression of Ductal Carcinoma In Situ to Invasive Carcinoma of the Breast

Discussion

Member takes

Implication

Key Points

Cite This Study

The Role of HER2/neu Overexpression/Amplification in the Progression of Ductal Carcinoma In Situ to Invasive Carcinoma of the Breast

Discussion

Member takes

Implication

Key Points

Cite This Study

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