The efficiency of spectral suppression, absorbance ratio and spectral overlay for peak purity testing using a diode array detector has been compared on a strongly overlapping model systea (cefotaxime and theophylline). Spectral overlay and spectral suppression have a comparable sensitivity (0.3 % of impurity can be detected) spectral suppression allows an accurate determination of impurity at 1% level; absorbance ratio is the less powerful technique.
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Fabre et al. (1992) studied this question.
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