What question did this study set out to answer?

To analyze the structural variation, polymorphism, and evolutionary history of Alu repetitive sequence clusters in the human low density lipoprotein (LDL) receptor gene.

November 1, 1985Proceedings of the National Academy of SciencesOpen Access

Polymorphism and evolution of Alu sequences in the human low density lipoprotein receptor gene.

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To analyze the structural variation, polymorphism, and evolutionary history of Alu repetitive sequence clusters in the human low density lipoprotein (LDL) receptor gene.
Characterized genomic DNA structure and sequence variation across two distinct Alu clusters in the human LDL receptor gene.
Performed Southern blot hybridization using cloned cDNA probes across human, primate, and bovine genomic DNA samples.
Identified a polymorphic Pvu II restriction site in the intron between exons 15 and 16, resulting from an adenine-to-guanine transition within an Alu repetitive element that yields 14-kb and 16.5-kb alleles.
Demonstrated that an Alu cluster in exon 18 integrated approximately 30 million years ago in the primate lineage through two independent insertion events, absent in bovine DNA.

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Implication

Genetic analysis reveals Alu sequence polymorphism and evolutionary insertion history in the human LDL receptor gene, highlighting mechanisms of primate genome diversification.

Cite This Study

Hobbs et al. (1985) studied this question.

synapsesocial.com/papers/6a6f55ce2163a0a01bc3a5c3 https://doi.org/10.1073/pnas.82.22.7651

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Implication

Genetic analysis reveals Alu sequence polymorphism and evolutionary insertion history in the human LDL receptor gene, highlighting mechanisms of primate genome diversification.

Polymorphism and evolution of Alu sequences in the human low density lipoprotein receptor gene.

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Discussion

Implication

Cite This Study

Polymorphism and evolution of Alu sequences in the human low density lipoprotein receptor gene.

Key Points

Discussion

Implication

Cite This Study

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