Editorial: Rethink your exercise for precision migraine management

Q: What is the clinical evidence from this study?

Study design: Editorial. Population: Migraine (n=253). Intervention: Aerobic exercise. Primary outcome: Pain intensity (SMD -1.1, 95% CI -1.72 to -0.47).

Q: What does this research mean for the field?

Aerobic exercise significantly reduces migraine pain intensity and frequency, with maximal benefits observed at 900–950 cumulative minutes over 10–11 weeks in a U-shaped dose-response relationship. Novelty: ClaimNovelty.SYNTHESIS. Consensus alignment: ConsensusAlignment.NEUTRAL.

Yohannes W. Woldeamanuel

doi:10.1111/head.15077

October 26, 2025Headache The Journal of Head and Face PainOpen Access

Editorial: Rethink your exercise for precision migraine management

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Key result

Aerobic exercise reduced migraine pain intensity, with maximal benefits observed at 900-950 cumulative minutes over 10-11 weeks.

PICO

P

Population

253 participants with migraine across 15 studies analyzed to determine the dose-response relationship of aerobic exercise for reducing pain intensity and frequency.

I

Intervention / Comparator

Aerobic exercise (900-950 minutes cumulatively (approx. 3 weekly 30-minute sessions))

O

Primary Outcome

Pain intensity — SMD -1.1 (-1.72 to -0.47)

Main Result

Standardized Mean Difference: -1.1 (95% CI -1.72–-0.47)

Limitations

Very-low certainty of evidence
Heterogeneity
Risk of bias
Small sample size
Lack of control groups
Variability in exercise modalities and intensity measurements

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Abstract

Yohannes Woubishet Woldeamanuel declares no conflict of interest.

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Cite This Study

Yohannes W. Woldeamanuel (2025) conducted an editorial in Migraine (n=253). Aerobic exercise was evaluated on Pain intensity (SMD -1.1, 95% CI -1.72 to -0.47). Aerobic exercise reduced migraine pain intensity, with maximal benefits observed at 900-950 cumulative minutes over 10-11 weeks.

synapsesocial.com/papers/6a6f55d675498292b708ba9c https://doi.org/10.1111/head.15077

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Editorial: Rethink your exercise for precision migraine management

PICO

Main Result

Limitations

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Abstract

Discussion

Cite This Study

Editorial: Rethink your exercise for precision migraine management

PICO

Main Result

Limitations

Ask about this paper

Abstract

Discussion

Cite This Study

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