Key result
A trivalent FMD vaccine containing 2.2 µg of 146S antigen per serotype per dose induced a protective dose 50 (GPPD50) of 88 in guinea pigs and maintained protective neutralizing antibody titers in cattle for 32 weeks.
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The study aims to determine the minimal effective dose of a trivalent FMD vaccine based on antigenic content.
Daoud et al. (2013) studied Foot and Mouth Disease (FMD). Trivalent FMD vaccine (types A, O, SAT2) vs. Unvaccinated controls and alternative doses (1.6 µg and 2.8 µg) was evaluated on Guinea pig protective dose 50 (GPPD50). A trivalent FMD vaccine containing 2.2 µg of 146S antigen per serotype per dose induced a protective dose 50 (GPPD50) of 88 in guinea pigs and maintained protective neutralizing antibody titers in cattle for 32 weeks.
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