June 1, 1979Infection and ImmunityOpen Access

Immunity to foot-and-mouth disease virus in guinea pigs: clinical and immune responses

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Population

Guinea pigs infected with foot-and-mouth disease virus (FMDV) type A12, strain 119

Design

Preclinical

Follow-up

Up to 4 days postinfection (kinetic studies)

Authors

RKRichard C. KnudsenCenters for Disease Control and Prevention CGC M GroocockAustralian Centre for Disease Preparedness AAArthur A. AndersenNational Animal Disease Center

Discussion

Member takes

Implication

Supports standardized FMDV immune assays in guinea pigs regardless of variables; leaves open translation to other species or vaccines.

Structured PICO

Population

Guinea pigs infected with foot-and-mouth disease virus (FMDV) type A12, strain 119

Intervention

Infection with different doses of FMDV administered by different routes (intradermal in tongue, heel pad, flank skin; intracardiac; subcutaneous)

Outcome

Clinical and immune responses (vesicle development, neutralizing antibody, immediate and delayed skin reactivity, macrophage migration inhibition factor production)surrogate

Guinea pigs infected with FMDV develop consistent humoral and cell-mediated immune responses regardless of inoculation route, dose, or disease severity.

Cite This Study

Knudsen et al. (1979) studied this question.

synapsesocial.com/papers/6a6f57198031ec7bb1dbb412 https://doi.org/10.1128/iai.24.3.787-792.1979

View Full Paper

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Immunity to foot-and-mouth disease virus in guinea pigs: clinical and immune responses

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Immunity to foot-and-mouth disease virus in guinea pigs: clinical and immune responses

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider