A Preliminary Study of the Pathogenesis of Foot-and-mouth Disease Virus Using in situ Hybridization

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Population

5 adult guinea pigs

Design

Preclinical

Follow-up

72 hours

Authors

Discussion

Early FMDV dissemination precedes lesions in guinea pig models; leaves open whether similar kinetics inform livestock surveillance or control timing.

Population

5 adult guinea pigs

Intervention

Intraepithelial inoculation in the right hindfoot pad with foot-and-mouth disease virus

Outcome

Detection of viral nucleic acid by in situ hybridization and microscopic evidence of virus-induced damagesurrogate

In a guinea pig model, foot-and-mouth disease virus disseminates widely to foot pads and tongue before microscopic lesions appear.

Brown et al. (1991) studied this question.

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Early FMDV dissemination precedes lesions in guinea pig models; leaves open whether similar kinetics inform livestock surveillance or control timing.