February 1, 1983Journal of General Virology

Protective Role of Foot-and-Mouth Disease Virus Antibody in vitro and in vivo in Guinea-pigs

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Population

In vitro and in vivo

Design

Preclinical

Authors

RKRichard C. KnudsenCenters for Disease Control and Prevention CGC M GroocockAustralian Centre for Disease Preparedness AAArthur A. AndersenNational Animal Disease Center

Discussion

Member takes

Implication

Dose thresholds distinguish systemic from local FMDV protection in guinea pigs; hypothesis-generating for passive immunization, pending validation in relevant species.

Structured PICO

Population

In vitro (swine kidney cell line, guinea-pig embryo tongue and heelpad cells) and in vivo (suckling mice, guinea-pigs)

Intervention

Immune serum from convalescent guinea-pigs infected with foot-and-mouth disease virus (FMDV) type A, strain 119

Outcome

Neutralization of FMDV and protection against primary vesicles and systemic spread

Antibody protection against systemic spread of FMDV may be due to infectious immune complexes being removed from the blood, whereas local protection requires very high antibody concentrations.

Cite This Study

Knudsen et al. (1983) studied this question.

synapsesocial.com/papers/6a86d741e0e6abca40d3ba84 https://doi.org/10.1099/0022-1317-64-2-341

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Implication

Dose thresholds distinguish systemic from local FMDV protection in guinea pigs; hypothesis-generating for passive immunization, pending validation in relevant species.

Protective Role of Foot-and-Mouth Disease Virus Antibody in vitro and in vivo in Guinea-pigs

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Protective Role of Foot-and-Mouth Disease Virus Antibody in vitro and in vivo in Guinea-pigs

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider