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Summary Antiserum to the virus of foot-and-mouth disease appears to contain at least two antibodies. The purified 25-mµ infective component of the virus has sites capable of combining with each antibody, whereas the noninfective 7-mµ component combines with one antibody only. The complement-fixing activity of an antiserum is the sum of two separate antibody activities to the 7-mµ and 25-mµ viral components and is not related in a simple way to the virus-neutralizing activity of the serum. The ratio of the complement-fixing activities of the antibodies to the 7 mµ and 25 mµ component of the virus is greater when adjuvant is used with the hyperimmunizing dose.
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B. Cartwright (1962) studied this question.
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